The Effect of Methyleneblue on Insulin and Glucagon Release Stimulated by Glucose and Arginine in the Isolated Perfused Rat Pancreas
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منابع مشابه
Effect of insulin on glucose- and arginine-stimulated somatostatin secretion from the isolated perfused rat pancreas.
The effects of exogenous insulin on somatostatin secretion from the isolated perfused rat pancreas have been investigated in the presence of 5.6 mM glucose and when somatostatin secretion was stimulated by either glucose (16.7 mM) or arginine (20 mM). Insulin (15 mU/ml) significantly and rapidly suppressed glucose- and arginine-stimulated somatostatin release. However, at 5.6 mM glucose and, in...
متن کاملEffect of muscimol on glucose-stimulated somatostatin and insulin release from the isolated, perfused rat pancreas.
This study examines the effect of muscimol, a high affinity, specific gamma-aminobutyric acid (GABA) agonist, on glucose-stimulated somatostatin and insulin release from the isolated, perfused rat pancreas. Perfusion with low glucose (50 mg/dl) conditions resulted in basal somatostatin release of 46 +/- 4 pg/ml. Basal insulin release was less than 20 microU/ml. High glucose (300 mg/dl) conditio...
متن کاملGlucose modulation of amino acid-induced glucagon and insulin release in the isolated perfused rat pancreas.
Interactions between glucose and arginine and a mixture of 20 amino acids found in normal rat serum were studied in the isolated perfused rat pancreas of normal rats, with release of immunoreactive glucagon and insulin as parameters. Secretion of both pancreatic hormones was low during the steady state, whether glucose (5 mM) was included in the perfusion medium or not. This glucose concentrati...
متن کاملCharacterization of the effects of arginine and glucose on glucagon and insulin release from the perfused rat pancreas.
To characterize the mechanisms by which arginine and glucose affect pancreatic alpha and beta cell function, the effects of these agents over their full dose response, both alone and in various combinations, were studied using the perfused rat pancreas. Arginine (0-38 mM), in the absence of glucose, stimulated biphasic glucagon (IRG) secretion (Km approximately 3-4 mM) at concentrations less th...
متن کاملEffect of glucose/sulfonylurea interaction on release of insulin, glucagon, and somatostatin from isolated perfused rat pancreas.
The effect of a sulfonylurea, glibenclamide, on the release of insulin, glucagon, and somatostatin was studied in the isolated perfused rat pancreas. At glucose concentrations of 1.1 mM or less, the drug stimulated somatostatin release, whereas glucagon release, after 2-3 min of increase, was markedly inhibited. Insulin release was moderately stimulated, and maximal release occurred relatively ...
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ژورنال
عنوان ژورنال: Folia Endocrinologica Japonica
سال: 1984
ISSN: 0029-0661
DOI: 10.1507/endocrine1927.60.6_729